Natural isohemagglutinin productionby the fetus
| Autor: | N. Matsaniotis, A. Agathopoulos, Th. Thomaidis |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
Male Immunodiffusion medicine.medical_specialty Immunoelectrophoresis Isohemagglutinin Hemagglutination tests Isoantibodies Fetus Pregnancy Internal medicine medicine Humans Antigens Mercaptoethanol Chromatography biology medicine.diagnostic_test business.industry Infant Newborn Infant Hemagglutination Tests Titer Endocrinology Immunoglobulin M Child Preschool Immunoglobulin G Antibody Formation Pediatrics Perinatology and Child Health Immunology Blood Group Antigens biology.protein Female Antibody business |
| Zdroj: | The Journal of Pediatrics. 74:39-48 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(69)80006-5 |
| Popis: | Natural isothemagglutinins were detected in the serum of 79 of 137 (57 per cent) randomly selected full-term newborn infants. Whether these isohemagglutinins were of the γM or γG type was determined by: (1) comparing isohemagglutinin titers before and after mercaptoethanol treatment of serum, since the latter selectively reduces bisulphide bonds of γM-globulin, thus inhibiting its antibody action; and (2) separating γM-globulins from γG-globulins of sera by Sephadex-gel filtration and testing for isohemagglutinin activity in the serum fractions. Only two infants had serum γA-globulins. Results showed that in a considerable proportion of neonatal sera, isohemagglutinins are of the γM type. Therefore, it is concluded that most fetuses produce their own isohemagglutinins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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