Influence of thyroid hormone on cortisol biosynthesis. A gaschromatographic analysis
| Autor: | G. Bellotti, C. Mengoli, A. Ros, A. Lechi, L.A. Scuro, G Montesi |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Thyroid Hormones endocrine system medicine.medical_specialty Adolescent Hydrocortisone endocrine system diseases Metabolite Cortodoxone Stimulation Hydroxylation Hyperthyroidism Biochemistry chemistry.chemical_compound Endocrinology Hypothyroidism Internal medicine Cosyntropin medicine Humans Aged Catabolism Adrenal cortex Thyroid Middle Aged medicine.anatomical_structure chemistry Adrenal Cortex Female hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Journal of Steroid Biochemistry. 13:445-447 |
| ISSN: | 0022-4731 |
| Popis: | The influence of thyroid hormone on the functional activity of adrenal 11β-hydroxylating enzyme in cortisol biosynthesis was evaluated indirectly by measuring in 43 adult subjects (17 hyperthyroids, 6 hypothyroids and 20 controls) the ratio between the main catabolic product of 11-deoxycortisol, tetrahydrodeoxycortisol (THS), and the sum of the 6 main cortisol catabolic products (“cortisol metabolites”). All these steroids were studied by means of a gas-liquid chromatographic analysis of total neutral fraction on the 24h urine output. The test was made after corticotrophic stimulation with 1 mg tetracosatrin (Synacthen Depot®) injected intramuscularly. The value of THS/cortisol metabolite ratio was 0.042 ± 0.006 in hyperthyroids, 0.090 ± 0.040 in hypothyroids, and 0.040 ± 0.008 in normal subjects. The difference between hypothyroids and controls was significant (P < 0.05). The results are briefly discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|