Carbohydrate antigen 125 predicts long-term mortality in African American patients with acute decompensated heart failure
Autor: | Ibrahim N. Mansour, M. Tarek Alahdab, Sirikarn Napan, Thomas D. Stamos |
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Rok vydání: | 2010 |
Předmět: |
Male
medicine.medical_specialty endocrine system diseases Acute decompensated heart failure Population Comorbidity Emergency Nursing Gastroenterology Sensitivity and Specificity Statistics Nonparametric Internal medicine Natriuretic Peptide Brain medicine Humans Intensive care medicine education Survival analysis Heart Failure education.field_of_study business.industry Hazard ratio Middle Aged medicine.disease Prognosis Survival Analysis female genital diseases and pregnancy complications Confidence interval Black or African American Quartile ROC Curve Echocardiography Heart failure CA-125 Antigen Cohort Acute Disease Luminescent Measurements Emergency Medicine Female Cardiology and Cardiovascular Medicine business Biomarkers |
Zdroj: | Congestive heart failure (Greenwich, Conn.). 16(1) |
ISSN: | 1751-7133 |
Popis: | The goal of this study was to evaluate the relation between serum levels of carbohydrate antigen 125 (CA125) and prognosis in African American (AA) patients with heart failure (HF). Little is known about the usefulness of CA125 in the AA population, which has different pathophysiology and higher prevalence of HF. The authors enrolled 172 consecutive AA patients (mean age, 55.8 years; 61.1% men) admitted with a clinical diagnosis of acute decompensated HF. CA125 was measured within 48+/-12 hours of presentation. Patients were grouped according to CA125 levels into quartiles. The median CA125 level was 16 U/mL. Serum levels of CA125 were elevated (>35 U/mL) in 58 patients (33.7%). Fifty-two patients (30.8%) died over a median follow-up period of 40 months. The CA125 threshold derived from the receiver operating characteristic curves for the prediction of mortality was 35 U/mL. In a multivariate analysis, CA125 levels >35 U/mL were found to be predictive of 40-month all-cause mortality (adjusted hazard ratio, 2.53; confidence interval, 1.40-4.59; P=.002). However, CA125 levels were not associated with 18-month HF rehospitalization. CA125 value is a strong and independent predictor of long-term mortality in AA patients admitted with a diagnosis of acute decompensated HF. Identifying a higher-risk cohort might allow for a more targeted treatment approach. |
Databáze: | OpenAIRE |
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