Immunostimulation of tumor microenvironment by targeting tumor-associated macrophages with hypoxia-responsive nanocomplex for enhanced anti-tumor therapy

Autor:	Yeoul, Kang, Junha, Lim, Gurusamy, Saravanakumar, Jinseong, Kim, Mihyeon, Park, Sooseok, Im, Won Jong, Kim
Rok vydání:	2022
Předmět:	Mice Neoplasms Tumor-Associated Macrophages Tumor Microenvironment Animals Pharmaceutical Science Immunization CD8-Positive T-Lymphocytes Hypoxia Polyethylene Glycols
Zdroj:	Journal of Controlled Release. 343:78-88
ISSN:	0168-3659
Popis:	Tumor-associated macrophages (TAMs), which dampen the therapeutic efficacy of cancer immunotherapy, are the key players in the immunosuppressive tumor microenvironment (TME). Therefore, reprogramming TAMs into tumoricidal M1 macrophages possesses considerable potential as a novel immunotherapy. However, the low bioavailability of polarization agents and limited accumulation of TAMs restrict their anti-tumor efficacy. In this study, we developed a polymer-based hypoxia-responsive nanocomplex to target TAMs in hypoxia for enhanced cancer immunotherapy. We synthesized a hypoxia-cleavable polymer poly(ethylene glycol)-azo-poly(
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f33ba34886cb34525521647e6eeec4a https://doi.org/10.1016/j.jconrel.2022.01.021 Zobrazit plný text záznamu Full Text from ScienceDirect