Mesangial Glomerulonephropathy with Decreased Circulating C4 and Predominant Mesangial C4 Deposition in Association with One Null Gene at the C4B Locus
| Autor: | James O. Wells, Edmund Bourke, John A. Bryan, Wallace G. Campbell |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Immunodiffusion medicine.medical_specialty Pathology Adolescent Fluorescent Antibody Technique Locus (genetics) Nephropathy Glomerulonephritis Internal medicine Complement C4b medicine Humans Gene Hematuria medicine.diagnostic_test biology business.industry Complement C4 Complement C3 medicine.disease Glomerular Mesangium Immunoglobulin A Phenotype Endocrinology biology.protein Renal biopsy Antibody business Weakly-reactive Recurrent microscopic hematuria |
| Zdroj: | Nephron. 43:128-132 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000183811 |
| Popis: | We report a case of mesangial glomerulonephropathy associated with decreased circulating C4 in a young man with recurrent microscopic hematuria and one null gene at the C4B locus. Mesangial deposits moderately reactive with anti-C4 and weakly reactive with anti-C3 and anti-IgA were found on renal biopsy. No evidence was found to support a diagnosis of IgA nephropathy or any other of the recently described mesangial glomerulonephropathies with immunoglobulin and complement deposition. This case apparently represents a unique, heretofore undescribed variant of mesangial glomerulonephropathy associated with mesangial C4 deposition and C4 hypocomplementemia. |
| Databáze: | OpenAIRE |
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