Model for end-stage liver disease score in the first 3 weeks after liver transplantation as a predictor for long-term outcome

Autor: Boeyuekkishi Agayev, Lorenz Frey, Alexander L. Gerbes, Martin K. Angele, Andrej Khandoga, Markus Guba, Emil Iskandarov, Jens Werner, Karl-Walter Jauch
Rok vydání: 2016
Předmět:
Zdroj: European Journal of Gastroenterology & Hepatology. 28:153-158
ISSN: 0954-691X
Popis: BackgroundEarly allograft dysfunction after liver transplantation (LTX) is not well defined. The aim of this study was to evaluate the value of early post-transplant model for end-stage liver disease (MELD) scores for predicting long-term outcome after transplantation.MethodsIn this single-center retrospective study, 362 consecutive patients after LTX were included. MELD scores at 7, 14, and 21 postoperative days (PODs) were calculated from primary lab values. Receiver operating characteristic (ROC) analyses were carried out to determine the critical cutoff MELD scores for patient and graft survival.ResultsOne year after transplantation, the patient and graft survival rates were 85 and 69%, respectively. Although pretransplant MELD scores were similar, they were significantly different at POD7, POD14, and POD21 between patients who died and those who survived the first year after transplantation. As shown by ROC curves, for patient survival, the optimal time point is POD14 with a cutoff MELD of 17. At this time point, patients with a MELD below 17 showed a 1-year survival rate of 94.3% and patients with a MELD of 17 and higher showed a 1-year survival rate of only 75.4%. For graft survival, the optimal time point was day 7 and a cutoff MELD of 29 (92% at MELD
Databáze: OpenAIRE