Tag7-Mts1 Complex Activates Chemotaxis of Regulatory T Cells

Autor:	O. K. Ivanova, T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin, G. P. Georgiev
Rok vydání:	2022
Předmět:	Chemotaxis Neoplasms Biophysics Humans Cytokines General Chemistry General Medicine Lymphocytes Biochemistry T-Lymphocytes Regulatory
Zdroj:	Doklady. Biochemistry and biophysics. 506(1)
ISSN:	1608-3091
Popis:	Abstract One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions of Treg, and investigation of this subpopulation is important for development of new therapeutic approaches. In this study, we demonstrate that regulatory T cells can migrate along the concentration gradient of Tag7–Mts1 complex, and also they produce agents that induce blood cells migration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f31c57b9b29955bf9b76392c61f292f https://pubmed.ncbi.nlm.nih.gov/36303048 Zobrazit plný text záznamu Full text from SpringerLink