Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: Study design of Carotid Plaque Composition Study
| Autor: | Andrew B. Moore, Xue Qiao Zhao, Colin D Lee, J.Theodore Dodge, Binh An P. Phan, Baocheng Chu, Nayak L. Polissar, Frank Bray, Thomas S. Hatsukami, Chun Yuan |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Pathology Colesevelam Hydrochloride Niacin Allylamine Coronary artery disease Double-Blind Method Diabetes mellitus Internal medicine Atorvastatin medicine Humans Carotid Stenosis Pyrroles Prospective Studies Myocardial infarction Prospective cohort study Hypolipidemic Agents medicine.diagnostic_test Colesevelam Vascular disease business.industry Magnetic resonance imaging Middle Aged Atherosclerosis Lipid Metabolism medicine.disease Magnetic Resonance Imaging Heptanoic Acids Cardiology Female Metabolic syndrome Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Heart Journal. 154:239-246 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/j.ahj.2007.04.035 |
| Popis: | Background In vivo testing of the lipid depletion hypothesis in human beings during lipid-modifying therapy has not been possible until recent developments in magnetic resonance imaging (MRI). Trial Design The Carotid Plaque Composition Study is a prospective, randomized study designed to test the lipid depletion hypothesis in vivo. One hundred twenty-three subjects with coronary artery disease (CAD) or carotid disease and with levels of apolipoprotein B ≥120 mg/dL (low-density lipoprotein levels 100-190 mg/dL) were enrolled and randomized to (1) single therapy—atorvastatin alone, placebos for extended release (ER)–niacin and colesevelam; (2) double therapy—atorvastatin plus ER-niacin (2 g/d), and placebo for colesevelam; (3) triple therapy—atorvastatin, ER-niacin, plus colesevelam (3.8 g/d). All subjects will undergo MRI scans of bilateral carotid arteries at baseline and annually for 3 years for a total of 4 examinations while on active therapy. Among these 123 subjects with mean age of 55 years and mean body mass index of 30 kg/m 2 , 73% are male, 43% have a family history of premature cardiovascular disease, 37% have had a previous myocardial infarction, 80% have clinically established CAD, 52% are hypertensive, 12% have diabetes, 23% are current smokers, and 47% meet the criteria for metabolic syndrome. The baseline carotid disease is evaluated using a MRI-modified American Heart Association lesion type definition. Of the 123 enrolled subjects, 40% have type III lesions with small eccentric plaque, 52% have type IV to V lesions with a necrotic core, and only 4% have calcified plaque based on the most diseased carotid location. Conclusions The Carotid Plaque Composition Study uses a state-of-the-art imaging technology and comprehensive lipid management to test the plaque lipid depletion hypothesis in CAD subjects. |
| Databáze: | OpenAIRE |
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