The Chemical Compositions of Angelica pubescens Oil and Its Prevention of UV-B Radiation-Induced Cutaneous Photoaging
| Autor: | Dingkang Chen, Wanyi Pan, Xi Zheng, Shiya Huang, Lanyue Zhang, Zhiyun Du, Kun Zhang, Zhirong Ou, Zhirong Lin, Ping Su, Li Lin, Hanyi Huang |
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| Rok vydání: | 2018 |
| Předmět: |
Ultraviolet Rays
Photoaging Bioengineering Glutaric acid Biochemistry 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine medicine Oils Volatile Animals Molecular Biology Angelica Skin Mice Hairless biology Traditional medicine Biological activity General Chemistry General Medicine medicine.disease biology.organism_classification Hairless Skin Aging Eugenol chemistry Mechanism of action 030220 oncology & carcinogenesis Molecular Medicine Female medicine.symptom Sunscreening Agents Uv b radiation Angelica pubescens |
| Zdroj: | Chemistrybiodiversity. 15(10) |
| ISSN: | 1612-1880 |
| Popis: | Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases. However, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti-photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) -B radiation-induced hairless mice. Overall, we identified and analyzed 93 compounds from the AO by gas chromatography-mass spectrometry (GC/MS). The top ten compounds were as follows: osthole (44.608%), glutaric acid hexadecyl pent-4-en-1-yl ester (5.758%), α-bisabolol (3.795%), eugenol (3.637%), (Z)-docos-13-enamide (3.286%), (3S,3aR)-3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one (3.043%), m-cresol (2.841%), trans-sesquisabinene hydrate (2.128%), 4-hydroxy-2-methylacetophenone (1.735%), and (Z)-9-pentadecenol (1.509%). Application of AO improved the condition of UV-B radiation-induced damaged skin, and the mechanism of action was found to be related to inhibition of the production of inflammatory cytokines. These results highlight the potential application of AO for the development of skin care products. |
| Databáze: | OpenAIRE |
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