Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19
| Autor: | Liya Li, Libo Tang, Qian Jiao, Yaping Wang, Haiyan Shi, Zhipeng Liu, Yujuan Guan, Baolin Liao, Yanxia Liu, Min Xie, Linghua Li, Weilie Chen, Xi He, Chunliang Lei, Qingxin Gan, Han Zhao, Yi Cao, Yaling Shi, Yongyin Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Radiography chest CT Lung injury Gastroenterology CD19 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans pulmonary injury Longitudinal Studies Lymphocyte Count Young adult Interleukin 6 Aged Retrospective Studies sequential monitoring Aged 80 and over biology business.industry SARS-CoV-2 interleukin-6 Interleukin COVID-19 Retrospective cohort study General Medicine Lung Injury Middle Aged biology.protein 030211 gastroenterology & hepatology Female Radiography Thoracic business Tomography X-Ray Computed CD8 Biomarkers Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Rationale: Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes of immunological and radiographic features, and the association with the outcome of pulmonary lesions in COVID-19 patients. Methods: Peripheral blood samples and radiographic data were collected longitudinally for up to 8 weeks from 158 laboratory-confirmed COVID-19 patients. The chest computed tomography (CT) scans were scored based on a semi-quantification assessment according to the extent of pulmonary abnormalities; the temporal change of the immunological and radiographic features was analyzed. Results: Compared with mild and moderate patients, severe patients had significantly decreased counts of lymphocytes, CD4+ T cells, CD8+ T cells, and CD19+ B cells but dramatically elevated counts of neutrophils and levels of interleukin (IL)-6. Sequential monitoring showed a sustained increase in lymphocytes counts and significantly decreased levels of IL-6 in severe patients during the disease course. Notably, patients with persistent pulmonary lesions (CT score ≥ 5 in week 8) showed high levels of IL-6 during the follow-up period, compared with those with recovery lesions (CT score < 5 in week 8). More importantly, the peak expression of IL-6 prior to the aggravated lung injury was mainly found in patients with persistent lesions, and multivariate analysis showed that IL-6 level upon admission was an independent factor associated with the persistent pulmonary injury. Conclusion: Prolonged elevation of IL-6 is associated with persistent pulmonary lesions in COVID-19 patients. Sequential monitoring and timely intervention of IL-6 may favor the clinical management of COVID-19. |
| Databáze: | OpenAIRE |
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