White matter differences in euthymic bipolar I disorder : a combined magnetic resonance imaging and diffusion tensor imaging voxel-based study
| Autor: | Camilla Langan, Wim Van Hecke, Colm McDonald, Dara M. Cannon, Peter McCarthy, Stefan Sunaert, Gareth J. Barker, Alexander Leemans, Louise Emsell, Rachel Nolan |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Bipolar I disorder Bipolar Disorder Grey matter White matter Nuclear magnetic resonance Antimanic Agents Fractional anisotropy Outcome Assessment Health Care mental disorders medicine Cingulum (brain) Humans Bipolar disorder Gray Matter Biological Psychiatry Psychiatric Status Rating Scales medicine.diagnostic_test Magnetic resonance imaging Organ Size Middle Aged medicine.disease White Matter Psychiatry and Mental health Affect medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Lithium Compounds Human medicine Psychology Neuroscience Diffusion MRI |
| Zdroj: | Bipolar disorders |
| ISSN: | 1398-5647 |
| Popis: | Emsell L, Langan C, Van Hecke W, Barker GJ, Leemans A, Sunaert S,McCarthy P, Nolan R, Cannon DM, McDonald C. White matterdifferences in euthymic bipolar I disorder: a combined magneticresonance imaging and diffusion tensor imaging voxel-based study.Bipolar Disord 2013: 15: 365–376. © 2013 John Wiley & Sons A/S.Published by John Wiley & Sons Ltd.Objectives: A broad range of subtle and markedly heterogenousneuroanatomical abnormalities of grey matter and white matter havebeen reported in bipolar disorder. Euthymic bipolar disorder patientsrepresent a clinically homogenous group in which to identify trait-basedbiomarkers of bipolar disorder. In this study, we sought to clarify thenature and extent of neuroanatomical differences in a large, clinicallyhomogeneous group of euthymic bipolar disorder patients.Methods: Structural magnetic resonance imaging (sMRI) was obtainedfor 60 patients with prospectively confirmed euthymic bipolar I disorderand 60 individually age- and gender-matched healthy volunteers. Highangular resolution diffusion tensor imaging (DTI) scans were obtainedfor a subset of this sample comprising 35 patients and 43 controls. Voxel-based analysis of both sMRI and DTI data sets was performed.Results: Bipolar disorder patients displayed global reductions in whitematter volume and fractional anisotropy reductions in the corpuscallosum, posterior cingulum, and prefrontal white matter comparedwith controls. There were corresponding increases in radial diffusivity inthe callosal splenium in patients compared with controls. No significantgroup differences were detected in grey matter. In patients, lithium wasassociated with a bilateral increase in grey matter volume in the temporallobes, but not with any DTI parameter.Conclusions: Euthymic bipolar I disorder is characterized by both diffuseglobal white matter deficits and potential regional disorganization ininterhemispheric and longitudinal tracts, while grey matter appears to bepreserved. |
| Databáze: | OpenAIRE |
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