Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties

Autor: Edenil Costa Aguilar, A.C.C. Ribeiro, Priscilla Ceci Lages, Tatianna Lemos Jascolka, Érica Leandro Marciano Vieira, Jacqueline I. Alvarez-Leite, Lílian Gonçalves Teixeira, Maria do Carmo Gouveia Peluzio
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Antioxidant
Physiology
medicine.medical_treatment
medicine.disease_cause
Biochemistry
Antioxidants
Soybean oil
Cholesterol
Dietary
Lipid peroxidation
Mice
chemistry.chemical_compound
Food science
General Pharmacology
Toxicology and Pharmaceutics
Carotenoid
lcsh:QH301-705.5
chemistry.chemical_classification
lcsh:R5-920
biology
medicine.diagnostic_test
General Neuroscience
food and beverages
General Medicine
Lipids
Cholesterol
Female
lcsh:Medicine (General)
food.ingredient
Short Communication
Immunology
Biophysics
Caryocar brasiliense
food
Pequi oil
Dietary Fats
Unsaturated
medicine
Animals
Cell Biology
biology.organism_classification
Fatty acid
Atherosclerosis
Soybean Oil
Mice
Inbred C57BL
chemistry
lcsh:Biology (General)
Oxidative stress
Dietary Supplements
Diet
Atherogenic
Lipid Peroxidation
Lipid profile
Ericales
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 45, Issue: 7, Pages: 601-609, Published: JUL 2012
Brazilian Journal of Medical and Biological Research, Vol 45, Iss 7, Pp 601-609 (2012)
Brazilian Journal of Medical and Biological Research v.45 n.7 2012
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV
Popis: O artigo não contém resumo em português. Pequi is the fruit of Caryocar brasiliense and its oil has a high concentration of monounsaturated and saturated fatty acids, which are anti- and pro-atherogenic agents, respectively, and of carotenoids, which give it antioxidant properties. Our objective was to study the effect of the intake of a cholesterol-rich diet supplemented with pequi oil, compared to the same diet containing soybean oil, on atherosclerosis development, and oxidative stress in atherosclerosis-susceptible LDL receptor-deficient mice (LDLr -/-, C57BL/6-background). Female mice were fed a cholesterol-rich diet containing 7% soybean oil (Soybean group, N = 12) or 7% pequi oil (Pequi group, N = 12) for 6 weeks. The Pequi group presented a more atherogenic lipid profile and more advanced atherosclerotic lesions in the aortic root compared to the Soybean group. However, the Pequi group presented a less advanced lesion in the aorta than the Soybean group and showed lower lipid peroxidation (Soybean group: 50.2 ± 7.1; Pequi group: 30.0 ± 4.8 µmol MDA/mg protein) and anti-oxidized LDL autoantibodies (Soybean group: 35.7 ± 9.4; Pequi group: 15.6 ± 3.7 arbitrary units). Peritoneal macrophages from the Pequi group stimulated with zymosan showed a reduction in the release of reactive oxygen species compared to the Soybean group. Our data suggest that a pequi oil-rich diet slows atherogenesis in the initial stages, possibly due to its antioxidant activity. However, the increase of serum cholesterol induces a more prominent LDL migration toward the intimae of arteries, increasing the advanced atherosclerotic plaque. In conclusion, pequi oil associated with an atherogenic diet worsens the lipid profile and accelerates the formation of advanced atherosclerotic lesions despite its antioxidant action.
Databáze: OpenAIRE
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