Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials
| Autor: | Lohitash Karumbaiah, Shuodan Chen, Wen Shen, Tarun Saxena, Ravi V. Bellamkonda, Mark G. Allen, Xi Liu, Radhika Patkar |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
extracellular matrix Materials Science (miscellaneous) immunohistology intracortical neural microelectrodes finite element analysis Penetration (firestop) electrophysiology Condensed Matter Physics Article Industrial and Manufacturing Engineering Atomic and Molecular Physics and Optics Extracellular matrix stress Microelectrode Electrophysiology bio-MEMS tissue-compliant electrodes Bio-MEMS Electrical and Electronic Engineering Elastic modulus Brain–computer interface Biomedical engineering Microfabrication |
| Zdroj: | Microsystems & nanoengineering |
| ISSN: | 2055-7434 |
| Popis: | Extracellular matrix (ECM)-based implantable neural electrodes (NEs) were achieved using a microfabrication strategy on natural-substrate-based organic materials. The ECM-based design minimized the introduction of non-natural products into the brain. Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions, thereby reducing inflammatory strain fields in the tissue. Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches. In vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs. |
| Databáze: | OpenAIRE |
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