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Hyperemesis gravidarum could cause weight loss of more than 5%, dehydration, and electrolyte loss. In this condition the body will metabolize fat, therefore, there is an increase in ketone level in the blood (ketosis) which can deplete the body's base reserve and cause acidosis as well as ketones in the urine (ketonuria). In some cases it can cause fetal death or even the mother. This study was aimed to obtain the description of urinary ketone in primigravids in first trimester with hyperemesis gravidarum in Manado. This was an observational descriptive study with a cross sectional design. Urine samples were taken by using non-probability sampling with consecutive sampling. The results showed 10 primigravids in first trimester with hyperemesis treated at Sitti Maryam Islamic Hospital Manado during November-December 2018. Based on the laboratory tests performed on all subjects, there were 3 primigravids (30%) who had ketonuria. Conclusion: Some primigravids in first trimester with hyperemesis gravidarum had ketonuria. Keywords: primigravids, first trimester, hyperemesis, ketonuria Abstrak: Pada hiperemesis gravidarum dapat terjadi penurunan berat badan hingga lebih dari 5%, dehidrasi, dan kehilangan elektrolit. Pada keadaan ini tubuh akan memetabolisme lemak sehingga terjadi peningkatan kadar keton dalam darah (ketosis) yang dapat menghabiskan cadangan basa tubuh dan menyebabkan asidosis serta terdapatnya keton dalam urin (ketonuria). Pada beberapa kasus dapat terjadi kematian janin maupun ibu. Penelitian ini bertujuan untuk mengetahui gambaran keton urin pada primigravida trimester I dengan hiperemesis gravidarum di Kota Manado. Jenis penelitian ialah deskriptif observasional dengan desain potong lintang. Sampel urin diambil dengan cara non-probability sampling jenis consecutive sampling. Hasil penelitian mendapatkan subyek penelitian yang terdiri dari 10 primigravida trimester 1 dengan hiperemesis yang dirawat di RS Islam Sitti Maryam Manado selama bulan November-Desember 2018. Berdasarkan hasil pemeriksaan laboratorium dari 10 subyek (100%) terdapat 3 primigravida (30%) yang mengalami keton-uria. Simpulan: Sebagian primigravida trimester I dengan hiperemesis gravidarum mengalami ketonuria. Kata kunci: primigravida, trimester 1, hiperemesis, ketonuria |
