Manganese-Based Nanoplatform As Metal Ion-Enhanced ROS Generator for Combined Chemodynamic/Photodynamic Therapy
| Autor: | Xiaochen Dong, Aihong Jiao, Wenjun Wang, Chen Liang, Nan Yang, Jiawei Zhu, Peng Wang, Xuejiao Song |
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| Rok vydání: | 2019 |
| Předmět: |
Porphyrins
Materials science Cell Survival medicine.medical_treatment Transplantation Heterologous Carbonates Mice Nude Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Redox Polyethylene Glycols Mice chemistry.chemical_compound In vivo Neoplasms Tumor Microenvironment medicine Animals Humans General Materials Science Photosensitizer Ions chemistry.chemical_classification Manganese Reactive oxygen species Photosensitizing Agents Chlorophyllides Singlet Oxygen Singlet oxygen Lasers Hydrogen Peroxide 021001 nanoscience & nanotechnology 0104 chemical sciences Photochemotherapy chemistry Biophysics Nanoparticles Hydroxyl radical Reactive Oxygen Species 0210 nano-technology Intracellular HeLa Cells |
| Zdroj: | ACS Applied Materials & Interfaces. 11:41140-41147 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.9b16617 |
| Popis: | Reactive oxygen species (ROS) with strong oxidizing and high activity have been regarded as an effective "weapon" for antitumor therapy, since it can induce organelle injury, oxidative damage, and cell death. Herein, hollow structured manganese carbonate (MnCO3) nanocubes are fabricated and loaded with photosensitizer (chlorin e6, Ce6), obtaining a responsive nanoplatform H-MnCO3/Ce6-PEG (HMCP NCs). Two different approaches to upregulate intracellular ROS level were realized by HMCP NCs. On one hand, with irradiation of external laser, Ce6 could generate singlet oxygen (1O2) through a multistep photochemical process applied in photodynamic therapy (PDT). On the other hand, MnCO3 could be specifically degraded into Mn2+ in an acidic tumor microenvironment (TME), triggering Mn2+-activated Fenton-like reaction to convert endogenous H2O2 into hydroxyl radical (•OH). In vitro combined chemodynamic therapy (CDT) and PDT showed that the metal ion-enhanced ROS production could break the intracellular redox equilibrium, thus leading to cell death. In vivo combined CDT/PDT with HMCP NCs exhibited remarkably enhanced therapeutic efficacy in inhibiting tumor growth, without resulting in noticeable damage to normal tissues. This work presents a unique type of manganese-based nanoplatform for efficiently generating ROS in solid tumors, favorable for ROS-involved therapeutic strategies. |
| Databáze: | OpenAIRE |
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