Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients
| Autor: | Kevin L. Behar, Ognen A. C. Petroff, Michael Hooten, John H. Krystal, Douglas L. Rothman, Víctor M. Navarro, Dennis S. Charney, Richard C. Delaney, Kitt Falk Petersen, Gerald I. Shulman, Ismene L. Petrakis |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Magnetic Resonance Spectroscopy Metabolite Encephalopathy Central nervous system Gastroenterology chemistry.chemical_compound Internal medicine Cortex (anatomy) medicine Humans Age of Onset Neurotransmitter Radionuclide Imaging Hepatic encephalopathy gamma-Aminobutyric Acid Cerebral Cortex business.industry Carnosine Middle Aged medicine.disease Psychiatry and Mental health Alcoholism medicine.anatomical_structure chemistry Cerebral cortex Hepatic Encephalopathy Protons business Complication |
| Zdroj: | The American journal of psychiatry. 156(6) |
| ISSN: | 0002-953X |
| Popis: | OBJECTIVE: The aim of the study was to compare levels of neuroactive amino acids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy. METHOD: Metabolite levels were measured in the occipital cortex by using spatially localized 1H-MRS. Five recently detoxified alcohol-dependent and five hepatic encephalopathy patients with alcohol and non-alcohol-related disease were compared with 10 healthy subjects. RESULTS: The combined level of γ-aminobutyric acid (GABA) plus homocarnosine was lower in the alcohol-dependent and hepatic encephalopathy patients than in the healthy subjects. CONCLUSIONS: The findings suggest that GABA-ergic systems are altered in both alcohol-dependent and hepatic encephalopathy patients. |
| Databáze: | OpenAIRE |
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