Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort
| Autor: | Kristin Benjaminsen Borch, Catherine Dong, Elisabete Weiderpass, Elio Riboli, Antonia Trichopoulou, Rudolf Kaaks, Claudia Agnoli, Michael Pawlita, Franck Carbonnel, Roel Vermeulen, Heiner Boeing, David J. Hughes, Amanda J. Cross, Julia Butt, Bethany Van Guelpen, Liher Imaz, Marc J. Gunter, Semi Zouiouich, José Ramón Quirós, Cecilie Kyrø, Mazda Jenab, Inger T. Gram, Aurora Perez-Cornago, Matthias B. Schulze, Alicia K Heath, Carlotta Sacerdote, Rosario Tumino, Eva Ardanaz, Jin Young Park, Carmen Santiuste, Anna Karakatsani, Domenico Palli, Tim Waterboer, Bas Bueno-de-Mesquita, Anne Tjønneland, Miguel Rodríguez-Barranco, Carlo La Vecchia, Antonio Agudo, Tilman Kühn, Marie-Christine Boutron-Ruault, Salvatore Panico, Sophia Harlid |
|---|---|
| Přispěvatelé: | Centre international de Recherche sur le Cancer (CIRC), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Gustave Roussy (IGR), Mode de vie, génétique et santé : études intégratives et transgénérationnelles (U1018 (Équipe 9)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Gustave Roussy (IGR), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Colorectal cancer Epidemiology [SDV]Life Sciences [q-bio] Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Medicine Humans Helicobacter Prospective Studies Prospective cohort study 11 Medical and Health Sciences biology Helicobacter pylori business.industry Cancer Odds ratio Middle Aged biology.organism_classification medicine.disease bacterial infections and mycoses digestive system diseases 3. Good health European Prospective Investigation into Cancer and Nutrition Europe 030104 developmental biology Oncology 030220 oncology & carcinogenesis Case-Control Studies Cohort Antibody Formation Female business Colorectal Neoplasms |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020, 29 (7), pp.1475-1481. ⟨10.1158/1055-9965.EPI-19-1545⟩ Cancer Epidemiology Biomarkers and Prevention, 29(7), 1475. American Association for Cancer Research Inc. |
| ISSN: | 1538-7755 1055-9965 |
| Popis: | Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00–1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19–2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99–1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|