PP075. Poor renal function following hypertensive pregnancy: Older mothers and smaller babies

Autor: Pamela Loughna, Fiona Broughton Pipkin, Anna Roberts, Amanda Green
Rok vydání: 2015
Předmět:
Zdroj: Pregnancy hypertension. 3(2)
ISSN: 2210-7789
Popis: Introduction There is increasing evidence that hypertensive pregnancy is a risk factor for renal disease [1]. Objectives To examine the correlation between maternal and offspring characteristics and impaired glomerular filtration rate following a hypertensive pregnancy. Method We calculated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) formula corrected for body surface area in a cohort of 422 women at 6 weeks following a pregnancy complicated by all types of hypertension (pre-eclampsia, gestational hypertension, essential hypertension with and without superimposed pre-eclampsia). We performed statistical analysis using Spearmans rho to examine for correlations with maternal and fetal characteristics. Results 2.1% women had poor renal function at 6 weeks after delivery with a GFR 2 . Older mothers were more likely to have a lower GFR ( p =0.001). Women with poor renal function at 6 weeks were more likely to have had a low birth weight baby ( p =0.002). The median birth weight for women with GFR 2 was 2.85kg as opposed to 3.23kg for women with a GFR >60ml/min/1.73m 2 . Conclusions Clinically significant renal impairment following a hypertensive pregnancy is a rare. Advancing maternal age represents an important risk factor for on-going renal disease in this population. Small babies are more likely in a hypertensive pregnancy [2] and may also represent a marker for poorer maternal health after birth in this population.
Databáze: OpenAIRE
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