Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study
| Autor: | Thorkil Ploug, Christina Petersen-Bønding, Cristina Michaelsen, Kristian Karstoft, Niklas Rye Jørgensen, Laura Kofoed Kjær, Emilie S. Andersen, Clara Lemoine, Tina Vilsbøll, Filip K. Knop, Henrik E. Poulsen, Emil List Larsen, Mark Lyngbæk, Matthew P. Gillum |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors FGF21 030209 endocrinology & metabolism Physical Therapy Sports Therapy and Rehabilitation Adaptive change Inflammation medicine.disease_cause Running Bone remodeling Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Orthopedics and Sports Medicine Chemistry 030229 sport sciences Oxidative Stress Endocrinology 8-Hydroxy-2'-Deoxyguanosine Creatinine Physical Endurance Nucleic acid Cytokines Bone Remodeling medicine.symptom Biomarkers Oxidative stress |
| Zdroj: | Journal of Sports Sciences. 38:2080-2091 |
| ISSN: | 1466-447X 0264-0414 |
| Popis: | Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h,8-oxodG: 8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography. |
| Databáze: | OpenAIRE |
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