A comparative study of carbohydrate antigen 19-9 in sickle cell disease subjects and controls in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
| Autor: | Paul Smith Davis Okpara, Ejike Nwane, Benedict Nwogho, Chide E Okocha, G O Chukwuma, P O Manafa, Nancy Lbeh, John C Aneke, V. I. Manafa |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Adolescent CA-19-9 Antigen Genotype Hemoglobin Sickle Cell Nigeria Anemia Sickle Cell Disease Severity of Illness Index Gastroenterology 030218 nuclear medicine & medical imaging Hospitals University Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Internal medicine Carcinoma Humans Medicine carbohydrate antigen 9-19 Hemoglobin phenotype business.industry Surrogate endpoint Age Factors Hemoglobin A Articles General Medicine medicine.disease Cross-Sectional Studies Hemoglobin phenotype disease severity carbohydrate antigen 9-19 pancreatic disease sickle cell disease medicine.anatomical_structure 030220 oncology & carcinogenesis Female disease severity sickle cell disease Seventy Nine Hemoglobin business pancreatic disease |
| Zdroj: | African Health Sciences; Vol 18, No 4 (2018); 1003-1009 African Health Sciences |
| ISSN: | 1680-6905 |
| DOI: | 10.4314/ahs.v18i4.21 |
| Popis: | Background: Sickle cell disease is characterized by chronic complications that affect almost all body organs. Pancreatic disease is rare in SCD. CA 19-9 is a non-specific surrogate marker for pancreatic disease especially carcinoma. CA 19-9 levels have not been evaluated in SCD patients in our environment. Objectives: The study aimed to compare the levels of CA 19-9 in homozygous sickle cell disease subjects in steady state with those of (Hb AS) and normal healthy subjects (Hb AA) Method: Seventy nine subjects including 39 Hb SS, 19 Hb AS and 21 Hb AA subjects were recruited in a cross-sectional study in Nnamdi Azikiwe University and Teaching Hospital. Haemoglobin genotype and CA 19-9 estimation were done using Hb electrophoresis and enzyme linked immunosorbent assay respectively. Data was analyzed with IBM SPSS 21. P value was set at 0.05. Result: The mean CA 19-9 (U/ml) level in Hb SS, Hb AS and Hb AA were 13.6 ± 7.6, 15.3 ± 9.9, and 20.0 ± 15.9 respectively. [Reference value |
| Databáze: | OpenAIRE |
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