Co-Existence of Hypertensive and Anti-Hypertensive Constituents, Synephrine, and Nobiletin in Citrus unshiu Peel
| Autor: | Yeryeon Jung, Ok-Nam Bae, Keunyoung Kim, Kyung Min Lim, Yiying Bian, Jung-Joon Kim, Jin Ho Chung, Thien Ngo |
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| Rok vydání: | 2019 |
| Předmět: |
Agonist
Citrus hypertension genetic structures medicine.drug_class Phytochemicals Pharmaceutical Science Pharmacology 01 natural sciences Nobiletin Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery medicine Vasoconstrictor Agents vasoconstriction Bioassay Citrus unshiu Physical and Theoretical Chemistry Antihypertensive Agents nobiletin biology Plant Extracts 010405 organic chemistry Chemistry Communication Organic Chemistry food and beverages Synephrine Flavones biology.organism_classification In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry bioassay Acorus gramineus Chemistry (miscellaneous) Molecular Medicine synephrine medicine.symptom Vasoconstriction medicine.drug |
| Zdroj: | Molecules, Vol 24, Iss 7, p 1197 (2019) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24071197 |
| Popis: | A single herb can contain multiple constituents with diverse bioactivities. We found that the extract of Citrus unshiu peel (CUP), induced abnormal vasoconstriction responses on the freshly isolated rat aortic rings in vitro. CUP stimulated the vasoconstriction alone, and it suppressed the phenylephrine-stimulated vasoconstriction. We studied the reasons behind this abnormal vasoconstriction pattern. Major constituents of CUP were determined and evaluated for their vaso-activities. Notably, synephrine, a contractile agonist, and nobiletin, newly identified to have anti-contractile activity co-existed in CUP. Synephrine and nobiletin competitively blocked or activated the same contractile targets resulting in contradicting and abnormal vasoconstriction responses. Accordingly, the vasoconstriction pattern varies significantly depending on the relative contents of synephrine and nobiletin in CUP. Interestingly, this response pattern could be observed with another plant extract, Acorus gramineus Sol. Collectively, we demonstrated that active ingredients with contradicting bioactivities could co-exist in a single plant extract, interact and produce abnormal response patterns in bioassay, which would give an important insight into the interpretation of unusual activity patterns induced by plant extracts. |
| Databáze: | OpenAIRE |
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