Antigenotoxic effects of (-)-epigallocatechin-3-gallate (EGCG) and its relationship with the endogenous antioxidant system, 8-hydroxydeoxyguanosine adduct repair (8-OHdG), and apoptosis in mice exposed to chromium(VI)

Autor:	Mario Altamirano-Lozano, Gabriela Serrano-Reyes, Lourdes Montserrat Hernández-Cortés, María del Carmen García-Rodríguez
Rok vydání:	2020
Předmět:	0301 basic medicine Chromium Male Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment chemistry.chemical_element Apoptosis Pharmacology Toxicology Antioxidants Catechin Adduct Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound DNA Adducts Mice 0302 clinical medicine medicine Animals Hexavalent chromium biology Antimutagenic Agents Glutathione Gallate 030104 developmental biology chemistry 8-Hydroxy-2'-Deoxyguanosine 030220 oncology & carcinogenesis biology.protein Environmental Pollutants
Zdroj:	Journal of toxicology and environmental health. Part A. 84(8)
ISSN:	1528-7394
Popis:	This study aimed to investigate the relationship between endogenous antioxidant system, 8-hydroxydeoxyguanosine adduct (8-OHdG) repair, and apoptosis in mice treated with chromium(VI) alone and in the presence of the antigenotoxic compound (-)-epigallocatechin-3-gallate (EGCG). Groups of 5 Hsd:ICR male mice were divided and treated as follows: (1) control, vehicle only; (2) EGCG, 8.5 mg/kg by gavage alone; (3) CrO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1a3ee233796f8431b9ec67fa14e08c https://pubmed.ncbi.nlm.nih.gov/33372577 Zobrazit plný text záznamu