A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias
| Autor: | Velimir A. Luketic, Chih Te Wu, M. Eric Gershwin, Paul A. Davis |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Immunoglobulin A Chemokine Cholangitis Sclerosing education Immunology Disease Biology Models Biological Primary sclerosing cholangitis Pathogenesis Electrolytes Primary biliary cirrhosis parasitic diseases medicine Bile Humans Immunology and Allergy Biliary Tract health care economics and organizations Ion Transport Liver Cirrhosis Biliary Cell adhesion molecule Epithelial Cells General Medicine medicine.disease Immunoglobulin A Secretory biology.protein Cytokines Bile Ducts Chemokines Signal transduction lcsh:RC581-607 Cell Adhesion Molecules Research Article |
| Zdroj: | Clinical and Developmental Immunology Clinical and Developmental Immunology, Vol 11, Iss 3-4, Pp 205-213 (2004) |
| ISSN: | 1740-2530 1740-2522 |
| DOI: | 10.1080/17402520400004177 |
| Popis: | Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|