Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant
| Autor: | Baisheng Li, Aiping Deng, Kuibiao Li, Yao Hu, Zhencui Li, Yaling Shi, Qianling Xiong, Zhe Liu, Qianfang Guo, Lirong Zou, Huan Zhang, Meng Zhang, Fangzhu Ouyang, Juan Su, Wenzhe Su, Jing Xu, Huifang Lin, Jing Sun, Jinju Peng, Huiming Jiang, Pingping Zhou, Ting Hu, Min Luo, Yingtao Zhang, Huanying Zheng, Jianpeng Xiao, Tao Liu, Mingkai Tan, Rongfei Che, Hanri Zeng, Zhonghua Zheng, Yushi Huang, Jianxiang Yu, Lina Yi, Jie Wu, Jingdiao Chen, Haojie Zhong, Xiaoling Deng, Min Kang, Oliver G. Pybus, Matthew Hall, Katrina A. Lythgoe, Yan Li, Jun Yuan, Jianfeng He, Jing Lu |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Time Factors
Multidisciplinary Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 Epidemiology Science COVID-19 General Physics and Astronomy General Chemistry Viral Load Virus Replication Article General Biochemistry Genetics and Molecular Biology Disease Outbreaks Virus Shedding Viral infection Chlorocebus aethiops Animals Humans RNA-Seq Contact Tracing Vero Cells |
| Zdroj: | Nature Communications Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022) |
| Popis: | The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequential PCR testing of quarantined individuals indicated that the viral loads of Delta infections, when they first become PCR-positive, were on average ~1000 times greater compared to lineage A/B infections during the first epidemic wave in China in early 2020, suggesting potentially faster viral replication and greater infectiousness of Delta during early infection. The estimated transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in 29 donor-recipient transmission pairs. However, the transmission of minor iSNVs resulted in at least 3 of the 34 substitutions that were identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread. The SARS-CoV-2 Delta variant has spread rapidly worldwide. Here, the authors characterise a single chain of transmission of Delta in China, and find evidence that it is more infectious and replicates faster during early infection compared to early pandemic lineages. |
| Databáze: | OpenAIRE |
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