Definition of Iron Deficiency Based on the Gold Standard of Bone Marrow Iron Staining in Heart Failure Patients
| Autor: | Edo Vellenga, Peter van der Meer, Niels Grote Beverborg, Sjoerd K. Bulstra, Adriaan A. Voors, Joost L. van Pelt, Dirk J. van Veldhuisen, Wouter C. Meijers, Rudolf A. de Boer, Dorine W. Swinkels, Massimo A. Mariani, Haye H. van der Wal, Eline L. Vegter, IJsbrand T. Klip, Andre B. Mulder |
|---|---|
| Přispěvatelé: | Cardiovascular Centre (CVC), Public Health Research (PHR), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL) |
| Rok vydání: | 2017 |
| Předmět: |
Male
STORES 030204 cardiovascular system & hematology GUIDELINES Gastroenterology EXERCISE CAPACITY Ventricular Function Left 0302 clinical medicine Bone Marrow 030212 general & internal medicine chemistry.chemical_classification Aged 80 and over biology Anemia Iron-Deficiency OVERLOAD Iron deficiency Iron Deficiencies Middle Aged Prognosis ferric carboxymaltose medicine.anatomical_structure SATURATION SURVIVAL Female Cardiology and Cardiovascular Medicine medicine.medical_specialty Anemia DIAGNOSIS TRANSFERRIN 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center transferrin saturation Internal medicine medicine Humans ANEMIA Aged Heart Failure Staining and Labeling Transferrin saturation business.industry ferritin medicine.disease Staining Ferritin Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] chemistry Transferrin Heart failure Ferritins biology.protein Bone marrow business Biomarkers Iron Compounds |
| Zdroj: | Circulation-Heart failure, 11(2):004519. LIPPINCOTT WILLIAMS & WILKINS Circulation. Heart Failure, 11, 2, pp. Circulation. Heart Failure, 11, |
| ISSN: | 1941-3297 1941-3289 |
| Popis: | Background The most commonly used definition of iron deficiency (ID; ferritin Methods and Results Bone marrow aspiration with iron staining was performed in 42 patients with HF and a reduced left ventricular ejection fraction (≤45%) undergoing median sternotomy for coronary artery bypass grafting. Patients were mostly male (76%) with mild-to-moderate HF and a mean age of 68±10 years. Bone marrow ID was found in 17 (40%) of the HF patients. The most commonly used definition of ID had a sensitivity of 82% and a specificity of 72%. A definition solely based on TSAT ≤19.8% or serum iron ≤13 µmol/L had a sensitivity of 94% and specificity of 84% and 88%, respectively ( P Conclusions A TSAT ≤19.8% or a serum iron ≤13 µmol/L shows the best performance in selecting patients with ID and identifies HF patients at the highest risk of death. Our findings validate the currently used TSAT cutoff of |
| Databáze: | OpenAIRE |
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