Sex-dependent variations in anti-nociceptive and antipyretic effects of rhizome and stem extract of Schumannianthus dichotomus Roxb. in male and female mice
| Autor: | Irin Karim, Md. Rafiul Hoque, Roni Roy, Mohammad Anwarul Basher, Afroza Akter, Tanaya Bhowmik, Sazzad Hosen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Traditional medicine Flavonoid Pharmaceutical Science Pharmacy Biology Rhizome RS1-441 Sexual dimorphism 03 medical and health sciences Pharmacy and materia medica 0302 clinical medicine Nociception schumannianthus dichotomus swiss albino mice sex dimorphism antinociceptive antipyretic Phytochemical chemistry medicine Pharmacology (medical) Antipyretic Hot plate test Licking 030217 neurology & neurosurgery 030304 developmental biology medicine.drug |
| Zdroj: | Indonesian Journal of Pharmacy, Pp 323–334-323–334 (2020) |
| ISSN: | 2338-9486 2338-9427 |
| DOI: | 10.22146/ijp.602 |
| Popis: | Schumannianthus dichotomus (Roxb.) Gagnep is a perennial shrub from Marantaceace family. The species is widely distributed in South and South-Asian countries. In traditional medicine, rhizome of the plant is used in fever and skin diseases and stem is used in earache. We aimed to substantiate these therapeutic claims by examining their effects in male and female mice model. Antinociceptive effect was evaluated by formalin induced hind paw licking, acetic acid induced writhing and hot plate test, and antipyretic effect was tested by yeast induced hyperthermia experiment. Doses of rhizome and stem extracts were 200 and 400 mg/kg.bw. Influence of mice sexes on these pharmacological effects was examined by performing experiments separately on male and female mice model. Qualitative phytochemical screening and quantitative analyses of total phenols and flavonoids were performed. Antinociceptive effects showed striking sex dimorphism. In hind paw licking test, male mice showed significant reductions (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|