Increased risk of depressive disorders in women with polycystic ovary syndrome
| Autor: | Elizabeth Hollinrake, Michelle Maifeld, Bradley J. Van Voorhis, Alison Abreu, Anuja Dokras |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Adolescent Population Body Mass Index Cohort Studies Risk Factors Internal medicine Surveys and Questionnaires medicine Odds Ratio Humans Interpersonal Relations Risk factor education Depression (differential diagnoses) Gynecology education.field_of_study Depressive Disorder business.industry Beck Depression Inventory Obstetrics and Gynecology Odds ratio Middle Aged medicine.disease Polycystic ovary female genital diseases and pregnancy complications Patient Health Questionnaire Reproductive Medicine Mood disorders Female business Polycystic Ovary Syndrome |
| Zdroj: | Fertility and sterility. 87(6) |
| ISSN: | 1556-5653 |
| Popis: | Polycystic ovary syndrome (PCOS) is associated with several metabolic complications. A few small studies have also suggested an increased risk of depression in women with PCOS. The goals of this study were to estimate the prevalence of depressive disorders in women with PCOS compared with controls and to evaluate the correlation between depression, hyperandrogenism, and other metabolic markers.Cohort study.University Hospital.Women with PCOS (Rotterdam criteria; n = 103). Women without PCOS seen during the same time period for an annual exam were used as control subjects (n = 103).Primary Care Evaluation of Mental Disorders Patient Health Questionnaire (PRIME-MD PHQ) and the Beck Depression Inventory.Depressive disorders.Women with PCOS were at an increased risk for depressive disorders (new cases) compared with controls (21% vs. 3%; odds ratio 5.11 [95% confidence interval (CI) 1.26-20.69]; P.03). The overall risk of depressive disorders in women with PCOS was 4.23 (95% CI 1.49-11.98; P.01) independent of obesity and infertility. Compared with the nondepressed PCOS subjects, the depressed PCOS subjects had a higher body mass index (BMI) and evidence of insulin resistance (P.02).We report a significantly increased risk of depressive disorders (as defined by the Diagnostic and Statistical Manual IV) in women with PCOS and recommend routine screening in this population. |
| Databáze: | OpenAIRE |
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