Benign and borderline phyllodes tumors of the breast: Clinicopathologic analysis of 205 cases with emphasis on the surgical margin status and local recurrence rate
| Autor: | Kayla Hackman, Iskender Sinan Genco, Lisa Ferreira, Bugra Tugertimur, Vaishali Purohit, Sabina Hajiyeva |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Reoperation 0301 basic medicine Surgical margin Pathology medicine.medical_specialty Adolescent Breast Neoplasms Negative margin Benign Phyllodes Tumor Pathology and Forensic Medicine Young Adult 03 medical and health sciences 0302 clinical medicine Phyllodes Tumor Margin (machine learning) medicine Humans Aged Retrospective Studies Positive margin business.industry Significant difference Margins of Excision Phyllodes tumor General Medicine Middle Aged medicine.disease Radiography 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Biopsy Large-Core Needle Radiology Neoplasm Recurrence Local Positive Surgical Margin business Follow-Up Studies |
| Zdroj: | Annals of Diagnostic Pathology. 51:151708 |
| ISSN: | 1092-9134 |
| DOI: | 10.1016/j.anndiagpath.2021.151708 |
| Popis: | Background The management of benign and borderline phyllodes tumors of the breast with a positive surgical margin is still controversial. Our aim in this study was to evaluate the impact of surgical margin status on the local recurrence rate of benign and borderline phyllodes tumors. Methods We reviewed 205 phyllodes tumors (191 benign, 14 borderline) that were surgically excised at our hospital between 2005 and 2019. Follow-up information extending to at least 6 months after surgery was retrieved from the clinical, radiology, and pathology records. Results The initial surgical margin was negative in 54 (26%) cases, close (≤ 1 mm) in 29 (14%) cases, and positive in 122 (60%) cases. Approximately half of the cases with a close margin and two-third of the cases with a positive margin underwent re-excision to obtain negative margins. Three (2.3%) local recurrences were observed among 131 cases with follow-up information, all three with benign phyllodes tumor. Of these three patients, one had a positive final margin, and two had negative final margins. There was no significant difference in the rate of local recurrence between PT with a positive surgical margin versus a close and negative margin. Conclusion The study results suggest that close clinical and radiologic follow-up may provide a better course of management rather than re-excision when managing positive margins in benign and borderline phyllodes tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect