Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration
| Autor: | Xunwu Hu, Toshio Sasaki, Enming Du, Sona Rani Roy, Ye Zhang, Dingze Mang, Shijin Zhang, Guanying Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Cell Membrane Permeability
Molecular Conformation 02 engineering and technology Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences chemistry.chemical_compound Electrochemistry Humans General Materials Science Semipermeable membrane Spectroscopy Toxins Biological Surfaces and Interfaces 021001 nanoscience & nanotechnology Condensed Matter Physics In vitro Transmembrane protein 0104 chemical sciences Cytolysis Monomer Membrane chemistry Cancer cell Biophysics Self-assembly 0210 nano-technology Hydrophobic and Hydrophilic Interactions HeLa Cells |
| Zdroj: | Langmuir. 35(23):7376-7382 |
| ISSN: | 0743-7463 |
| Popis: | Inspired by the metamorphosis of pore-forming toxins from soluble inactive monomers to cytolytic trans-membrane assemblies, we developed self-assembly-directed membrane insertion of synthetic analogues for permeability alteration. An expanded pi-conjugation-based molecular precursor with an extremely high rigidity and a long hydrophobic length that is comparable to the hydrophobic width of plasma membrane was synthesized for membrane-inserted self-assembly. Guided by the cancer biomarker expression in vitro, the soluble precursors transform into hydrophobic monomers forming assemblies inserted into the fluid phase of the membrane exclusively. Membrane insertion of rigid synthetic analogues destroys the selective permeability of the plasma membrane gradually. It eventually leads to cancer cell death, including drug resistant cancer cells. |
| Databáze: | OpenAIRE |
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