Blood Pressure Changes After Exposures Increasing Angiotensin-Converting Enzyme Activity and After Its Normalization with Dihydroquercetin in Male Wistar Rats
| Autor: | A. F. Korystova, Elena A Tukhovskaya, A. V. Lobanov, M. Kh. Levitman, Vera V. Shaposhnikova, L. N. Kublik, Yu. N. Korystov, Yu. A. Kim, G. A. Slashcheva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Blood Pressure Peptidyl-Dipeptidase A General Biochemistry Genetics and Molecular Biology Dexamethasone 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine medicine.artery Radiation Ionizing medicine Animals Enalapril Rats Wistar chemistry.chemical_classification Aorta biology Angiotensin-converting enzyme General Medicine Enzyme assay Rats 030104 developmental biology Endocrinology Blood pressure Enzyme NG-Nitroarginine Methyl Ester chemistry Enzyme inhibitor biology.protein Quercetin 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 166(1) |
| ISSN: | 1573-8221 |
| Popis: | Changes in BP and HR were assessed after exposures increasing activity of angiotensin-converting enzyme: ionizing radiation, NO synthase inhibitor (L-NAME), and dexamethasone. Effects of dihydroquercetin and angiotensin-converting enzyme inhibitor enalapril on activity of this enzyme, BP, and HR were also evaluated under these exposures. Wistar male rats were subjected to X-ray irradiation in a dose of 2.5 Gy. Angiotensin-converting enzyme activity in the aorta sections was determined by Hip-His-Leu hydrolysis. BP and HR were recorded using a non-invasive tail-cuff method and PowerLab 8/35 software. BP and HR were not altered with the increase in activity of angiotensin-converting enzyme after irradiation. In case of prolonged (7 days) treatment with NO synthase inhibitor and dexamethasone, the increase in enzyme activity was accompanied by elevation of BP and, in the case of NO synthase inhibitor, HR reduction. Dihydroquercetin normalized the enzyme activity and lowered BP, but not to the normal level. Enalapril normalized BP, increased by NO synthase inhibitor solution intake; at the same time, the angiotensinconverting enzyme activity decreased more than 2-fold in comparison with the normal. |
| Databáze: | OpenAIRE |
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