Effect of maternal preconceptional and pregnancy micronutrient interventions on children’s DNA methylation: Findings from the EMPHASIS study

Autor: Sara Sajjadi, Dilip K. Yadav, Matt J. Silver, Karen A. Lillycrop, Sirazul A. Sahariah, Philip James, Kalyanaraman Kumaran, Ayden Saffari, Ashutosh Singh Tomar, Modupeh Betts, Giriraj R. Chandak, Caroline H.D. Fall, Prachand Issarapu, Smeeta Shrestha, Andrew M. Prentice, Akshay Dedaniya
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Offspring
Quantitative Trait Loci
Psychological intervention
Medicine (miscellaneous)
law.invention
AcademicSubjects/MED00160
AcademicSubjects/MED00060
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Pregnancy
law
medicine
Humans
Micronutrients
micronutrient intervention
Child
Randomized Controlled Trials as Topic
DNA methylation
Nutrition and Dietetics
Prenatal nutrition
epigenetics
Obstetrics
business.industry
dNaM
Maternal Nutritional Physiological Phenomena
epigenome-wide association study
medicine.disease
Micronutrient
Neoplasm Proteins
Original Research Communications
030104 developmental biology
Child
Preschool
Cohort
Female
Gene-Environment Interaction
Proteoglycans
business
RCT
030217 neurology & neurosurgery
Zdroj: The American Journal of Clinical Nutrition
ISSN: 0002-9165
DOI: 10.1093/ajcn/nqaa193
Popis: Background: Maternal nutrition in pregnancy has been linked to offspring health in early and later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism. Objective: We investigated intervention-associated DNAm changes in children whose mothers participated in 2 randomized controlled trials of micronutrient supplementation before and during pregnancy, as part of the EMPHASIS (Epigenetic Mechanisms linking Preconceptional nutrition and Health Assessed in India and sub-Saharan Africa) study (ISRCTN14266771). Design: We conducted epigenome-wide association studies with blood samples from Indian (n = 698) and Gambian (n = 293) children using the Illumina EPIC array and a targeted study of selected loci not on the array. The Indian micronutrient intervention was food based, whereas the Gambian intervention was a micronutrient tablet. Results: We identified 6 differentially methylated CpGs in Gambians [2.5-5.0% reduction in intervention group, all false discovery rate (FDR)
Databáze: OpenAIRE
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