Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM)
| Autor: | Riitta Veijola, Mikael Knip, Paula Vähäsalo, K. Savola, Helena Reijonen, J Karjalainen, Jorma Ilonen, Hans K. Åkerblom, E Sabbah, Petri Kulmala |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Genotype medicine.medical_treatment Immunology 030209 endocrinology & metabolism Biology Islets of Langerhans 03 medical and health sciences Sex Factors 0302 clinical medicine HLA-DQ Antigens Immunopathology Internal medicine Diabetes mellitus medicine HLA-DQ beta-Chains Humans Insulin Immunology and Allergy Genetic Predisposition to Disease Child Autoantibodies 030304 developmental biology Autoimmune disease 0303 health sciences HLA-DQB1 Glutamate Decarboxylase Age Factors Autoantibody Infant Original Articles medicine.disease 3. Good health Diabetes Mellitus Type 1 Endocrinology Child Preschool biology.protein Female Antibody |
| Zdroj: | Clinical and Experimental Immunology. 116:78-83 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARY The possible relation between HLA-DQ genotypes and both frequencies and levels of autoantibodies associated with IDDM was assessed by examining HLA-DQB1 alleles and antibodies to islet cells (ICA), insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase-related IA-2 molecule (IA-2A) in 631 newly diagnosed diabetic children under the age of 15 years. ICA were found in 530 children (84.0%), while close to half of the subjects (n = 307; 48.7%) tested positive for IAA. GADA were detected in 461 index cases (73.1%), with a higher frequency in those older than 10 years (78.9% versus 69.2% in the younger ones; P = 0.006). More than 85% of the children (n = 541; 85.7%) tested positive for IA-2A. Altogether there were only 11 children (1.7%) who had no detectable autoantibodies at diagnosis. There were no differences in the prevalence of ICA or GADA between four groups formed according to their HLA-DQB1 genotype (DQB1*0302/02, *0302/X (X = other than *02), *02/Y (Y = other than *0302) and other DQB1 genotypes). The children with the *0302/X genotype had a higher frequency of IA-2A and IAA than those carrying the *02/Y genotype (93.8% versus 67.3%, P |
| Databáze: | OpenAIRE |
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