The effect of oxandrolone on voice frequency in growth hormone-treated girls with Turner syndrome
| Autor: | Leonie A. Menke, Theo C J Sas, Gladys R J Zandwijken, Maria A. J. de Ridder, Sophie van Koningsbrugge, Bart Boersma, Jan M. Wit, Sabine M.P.F. de Muinck Keizer-Schrama, Dejonckere Ph, Barto J. Otten |
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| Přispěvatelé: | Pediatrics, Epidemiology, General Paediatrics, ANS - Cellular & Molecular Mechanisms, ANS - Complex Trait Genetics, ARD - Amsterdam Reproduction and Development |
| Rok vydání: | 2011 |
| Předmět: |
VOICE DEEPENING
medicine.medical_specialty Adolescent Hormone Replacement Therapy Voice Quality Growth hormone therapy Turner syndrome Growth hormone Placebo Oxandrolone Speech and Hearing Anabolic Agents Internal medicine medicine Humans Estrogen replacement therapy Child Normal range Growth Disorders Dose-Response Relationship Drug Human Growth Hormone Follow up studies Infant Estrogens LPN and LVN medicine.disease Mitochondrial medicine [IGMD 8] Endocrinology Otorhinolaryngology Child Preschool Voice Voice frequency Female Psychology medicine.drug Follow-Up Studies |
| Zdroj: | Journal of Voice, 25, 602-10 Journal of Voice, 25(5), 602-610. Mosby Inc. Journal of Voice, 25(5), 602-610 Journal of Voice, 25, 5, pp. 602-10 Journal of voice, 25(5), 602-610. Mosby Inc. |
| ISSN: | 0892-1997 |
| Popis: | Objectives/Hypothesis. Oxandrolone (Ox) increases height gain but may also cause voice deepening in growth hormone (GH)-treated girls with Turner syndrome (TS). We assessed the effect of Ox on objective and subjective speaking voice frequency in GH-treated girls with TS. Study Design. A multicenter, randomized, placebo (Pl)-controlled, double-blind study was conducted. Methods. One hundred thirty-three patients were included and treated with GH (1.33 mg/m(2)/d) from baseline, combined with Pl or Ox in a low (0.03 mg/kg/d) or conventional (0.06 mg/kg/d) dose from the age of 8 years and estrogens from the age of 12 years. Yearly from starting Ox/Pl until 6 months after discontinuing GH + Ox/Pl, voices were recorded and questionnaires were completed. Results. At start, mean (+/- standard deviation [SD]) voice frequency SD score (SDS) was high for age (1.0 +/- 1.2, P < 0.001) but normal for height. Compared with GH + Pl, voices tended to lower on GH + Ox 0.03 (P = 0.09) and significantly lowered on GH + Ox 0.06 (P = 0.007). At the last measurement, voice frequency SDS was still relatively high in OH + PI group (0.6 +/- 0.7, P = 0.002) but similar to healthy girls in both OH + Ox groups. Voice frequency became lower than 2 SDS in one patient (3%) on OH + Ox 0.03 and three patients (11%) on GH + Ox 0.06. The percentage of patients reporting subjective voice deepening was similar between the dosage groups. Conclusions. Untreated girls with TS have relatively high-pitched voices. The addition of Ox to GH decreases voice frequency in a dose-dependent way. Although most voice frequencies remain within the normal range, they may occasionally become lower than -2 SDS, especially on OH + Ox 0.06 mg/kg/d. |
| Databáze: | OpenAIRE |
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