Walking in the Light: How History of Physical Activity, Sunlight, and Vitamin D Account for Body Fat—A UK Biobank Study
| Autor: | Yueying Wang, Scott T. Le, Tovah Wolf, Daniel W. Russell, Amy Pollpeter, Shan Yu, Nathan F. Meier, Brandon S. Klinedinst, Qian Wang, Jonathan P. Mochel, Brittany Larsen, David A. Bennett, Li Wang, Karin Allenspach, Auriel A. Willette, Colleen Pappas |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue 030209 endocrinology & metabolism White adipose tissue Article vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Vitamin D and neurology Humans Medicine Lipolysis Longitudinal Studies 030212 general & internal medicine Vitamin D skin and connective tissue diseases Exercise Aged Biological Specimen Banks Sunlight Nutrition and Dietetics business.industry Middle Aged medicine.disease Obesity United Kingdom Adipose Tissue Adipogenesis Female sense organs business |
| Zdroj: | Obesity (Silver Spring) |
| ISSN: | 1930-739X 1930-7381 |
| Popis: | OBJECTIVE: High prevalence of vitamin D deficiency and obesity drive the need for successful strategies that elevate vitamin D levels, prevent adipogenesis and stimulate lipolysis. We provide a theoretical model to evaluate how physical activity and sunlight exposure influence serum vitamin D levels and regional adiposity. We hypothesized posteriori that sunlight is associated with undifferentiated visceral adiposity by increasing the ratio of brown to white adipose tissue. METHODS: Using ten-year longitudinal data, accelerometry, a sun exposure questionnaire, and regional adiposity quantified by DEXA imaging, a structural equation mediation model of growth curves was constructed with data-driven methodology. RESULTS: Sunlight and physical activity conjointly increased serum vitamin D. Changes in vitamin D levels partially mediated how sunlight and physical activity impacted adiposity in visceral and subcutaneous regions within a subjective physical activity model. In an objective physical activity model, vitamin D was a mediator for subcutaneous regions only. Interestingly, sunlight was associated with less adiposity in subcutaneous regions, yet greater adiposity in visceral regions. CONCLUSIONS: Sunlight and physical activity may increase vitamin D levels. For the first time, we characterize a positive association between sunlight and visceral adiposity. Further investigation and experimentation are necessary to clarify the physiological role of sunlight exposure on adipose tissue. |
| Databáze: | OpenAIRE |
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