Signal Activation and Inactivation by the Gα Helical Domain: A Long-Neglected Partner in G Protein Signaling
| Autor: | Henrik G. Dohlman, Janice C. Jones |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
GTPase-activating protein
G protein GTP-Binding Protein alpha Subunits Cell Biology Oncogene Protein p21(ras) Biology Biochemistry Protein Structure Secondary Article Protein Structure Tertiary GPS2 Cell biology Enzyme Activation Protein structure Heterotrimeric G protein Animals Humans Molecular Biology Signal Transduction G protein-coupled receptor G alpha subunit |
| Zdroj: | Science Signaling. 5 |
| ISSN: | 1937-9145 1945-0877 |
| DOI: | 10.1126/scisignal.2003013 |
| Popis: | Heterotrimeric guanine nucleotide–binding proteins (G proteins) are positioned at the top of many signal transduction pathways. The G protein α subunit is composed of two domains, one that resembles Ras and another that is composed entirely of α helices. Historically, most attention has focused on the Ras-like domain, but emerging evidence reveals that the helical domain is an active participant in G protein signaling. |
| Databáze: | OpenAIRE |
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