New aspects of USP30 biology in the regulation of pexophagy
| Autor: | Jane Jardine, Michael J. Clague, Sylvie Urbé, Emma V Rusilowicz-Jones, Andreas Kallinos, Elena Marcassa |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
education.field_of_study 030102 biochemistry & molecular biology Autophagy Cell Biology Biology Peroxisome Mitochondrion Cell biology Green fluorescent protein Deubiquitinating enzyme 03 medical and health sciences 030104 developmental biology Sequestosome 1 Ubiquitin Mitophagy biology.protein education Molecular Biology |
| Zdroj: | AUTOPHAGY |
| ISSN: | 1554-8635 1554-8627 |
| Popis: | Mitochondria and peroxisomes have a number of features in common: they each play interconnected roles in fatty acid and reactive oxygen species (ROS) metabolism and, once damaged, need to be removed by specialized autophagic mechanisms, termed mitophagy and pexophagy, respectively. Both processes can use ubiquitin as an initiating signal but whereas mitophagy has been extensively studied, pexophagy remains rather poorly understood. Our recent work, along with a new study from Kim and colleagues, has shed light on the molecular mechanism of pexophagy and the importance of reversible ubiquitination in its regulation. Collectively, these studies highlight the physiological role of the deubiquitinase USP30 in suppressing the turnover of peroxisomes. Abbreviations: ROS: reactive oxygen species; DUB: deubiquitinase or deubiquitylase; USP: ubiquitin specific protease; PINK1: PTEN induced kinase 1; CAT: catalase; KO: knock-out; SQSTM1/p62: sequestosome 1; LIR: LC3 interacting region; GFP: green fluorescent protein; RFP: red fluorescent protein; CRISPR: Clustered Regularly Interspaced Short Palendromic Repeat. |
| Databáze: | OpenAIRE |
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