Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia
| Autor: | Bahattin Avci, Erdal Malatyalioglu, Handan Celik, Tayfun Alper, Erhan Yavuz, Migraci Tosun |
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| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Umbilical cord Preeclampsia preeclampsia Young Adult Pre-Eclampsia Pregnancy medicine Humans Interleukin 8 Young adult Interleukin 6 tumor necrosis factor-alpha reproductive and urinary physiology biology Obstetrics business.industry Interleukin-6 Tumor Necrosis Factor-alpha interleukin-6 Interleukin-8 Case-control study Obstetrics and Gynecology medicine.disease Fetal Blood female genital diseases and pregnancy complications medicine.anatomical_structure Case-Control Studies embryonic structures Pediatrics Perinatology and Child Health Immunology biology.protein Gestation Female business |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 23(8) |
| ISSN: | 1476-4954 |
| Popis: | AVCI, Bahattin/0000-0001-6471-6495 WOS: 000280592200018 PubMed: 20441409 Objectives. The aim of this study was to investigate the relationship of maternal and umbilical cord interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) serum levels with the existence and severity of preeclampsia. A particular objective was the comparison of normal umbilical serum levels to preeclamptic values. Materials and Methods. The study group consisted of 24 patients with third trimester singleton pregnancies complicated by preeclampsia (15 severe and 9 mild preeclampsia). The gestational age-matched 19 healthy pregnant women were compared by study group. Maternal and umbilical serum IL-6, IL-8, and TNF-alpha were calculated by using enzyme-linked immunosorbent assay. Results. Significantly increased maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha were found in preeclamptic patient group in comparison with the control group. Maternal serum IL-8 and TNF-alpha concentration were significantly higher in patients with severe preeclampsia than in mild preeclampsia. Increased umbilical serum levels of IL-6 and IL-8 were found in severe preeclampsia than in mild preeclampsia. There were significantly higher levels of maternal serum IL-8 and TNF-alpha in patients with preeclampsia with IUGR than in patients with preeclampsia with normal fetal growth. Conclusion. Our findings suggest that increased concentrations of IL-6, IL-8, and TNF-alpha in the maternal and umbilical serum play a significant role in pathogenesis of preeclampsia. Alterations in maternal and umbilical serum levels of IL-6, IL-8, and TNF-alpha may also play role in preeclampsia complicated by intrauterine growth retardation. These associations may offer insight into the etiology and pathogenesis of preeclampsia. |
| Databáze: | OpenAIRE |
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