Cytomegalovirus Status and the Outcome of T Cell-Replete Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation
| Autor: | Monique C. Minnema, Jürgen Kuball, Lotte van der Wagen, Anette van Dijk, Reinier Raymakers, Frans M. Verduyn Lunel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Transplantation Conditioning Adolescent Premedication medicine.medical_treatment Congenital cytomegalovirus infection Graft vs Host Disease Cytomegalovirus Reduced intensity Disease Hematopoietic stem cell transplantation Antiviral Agents Young Adult 03 medical and health sciences 0302 clinical medicine Journal Article Humans Transplantation Homologous Medicine Aged Retrospective Studies Transplantation Proportional hazards model Donor selection business.industry Hematopoietic Stem Cell Transplantation Stem cell transplantation virus diseases Hematology Middle Aged medicine.disease Survival Analysis Leukemia surgical procedures operative 030220 oncology & carcinogenesis Cytomegalovirus Infections Immunology Virus Activation Serostatus business Viral load 030215 immunology |
| Zdroj: | Biology of Blood and Marrow Transplantation, 22(10), 1883. Elsevier Inc. |
| ISSN: | 1083-8791 |
| Popis: | Cytomegalovirus (CMV) serostatus of donor and recipient are frequently used in algorithms of donor selection, whereas the impact of CMV reactivation on transplantation-related mortality, leukemia control, and overall survival (OS) remains controversial. Therefore, we retrospectively studied the impact of latent or active CMV infections on the outcome and occurrence of graft-versus-host disease (GVHD) after reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (SCT) in 294 patients during the period from 2004 to 2010. CMV viral load was routinely monitored in plasma using a quantitative PCR. Preemptive antiviral therapy was initiated when the viral load in plasma exceeded a predefined threshold. In a proportional hazards model, a seropositive recipient was significantly associated with increased occurrence of acute GVHD. However the CMV serostatus of both recipient and donor and the presence of active CMV infection was not associated with the occurrence of relapses, chronic GVHD, or OS. We conclude that in the presence of viral load monitoring and preemptive treatment, latent or active CMV infection does not substantially affect the OS after T cell–replete RIC allogeneic SCT. |
| Databáze: | OpenAIRE |
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