Correlation of DOTATOC Uptake and Pathologic Grade in Neuroendocrine Tumors
| Autor: | Li Zhang, Katherine Van Loon, Emily K. Bergsland, Thomas A. Hope, Hilary Chan, Christian Moseley, Miguel Hernandez Pampaloni |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male endocrine system Mitotic index Proliferation index Endocrinology Diabetes and Metabolism Neuroendocrine tumors Correlation 03 medical and health sciences 0302 clinical medicine Endocrinology Positron Emission Tomography Computed Tomography Internal Medicine medicine Mitotic Index Organometallic Compounds Humans Receptors Somatostatin Receptor Aged Retrospective Studies Aged 80 and over Neoplasm Grading Hepatology Somatostatin receptor business.industry Middle Aged medicine.disease Magnetic Resonance Imaging Neuroendocrine Tumors 030220 oncology & carcinogenesis Positron-Emission Tomography Cancer research 030211 gastroenterology & hepatology Female Radiopharmaceuticals Somatostatin analog business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pancreas. 48(7) |
| ISSN: | 1536-4828 |
| Popis: | Gallium (Ga)-DOTATOC is a somatostatin analog used to detect neuroendocrine tumors (NETs). Ki-67 proliferation index (Ki-67 PI) has been established as a prognostic factor in NETs. We aimed to evaluate whether a correlation exists between Ki-67 PI and somatostatin receptor positron emission tomography (SSTR-PET) uptake.We retrospectively reviewed 238 DOTATOC PET scans between 2014 and 2016. Patients were excluded if DOTATOC PET was performed more than 365 days from the date of biopsy. Maximum standardized uptake values (SUVmax) of SSTR-PET from biopsied lesions were measured and correlated with Ki-67 PI using the Pearson correlation coefficient.Among 110 lesions from 90 patients, DOTATOC PET had 92.7% sensitivity and 100% specificity (102 true positives, 8 false negatives) for detection of NETs. Among 63 lesions from 54 patients with Ki-67 PI available, there were 27 grade 1 lesions [median Ki-67 PI, 1.0%; interquartile range (IQR), 1.0-2.0], 30 grade 2 lesions (median, Ki-67 PI 7.5%; IQR, 5-10), and 6 grade 3 lesions (median Ki-67 PI, 30%; IQR, 26-34). There was a correlation between Ki-67 PI and SUVmax (r = -0.3, P = 0.018).Our analysis demonstrates an inverse correlation between Ki-67 PI and SUVmax in NETs. Somatostatin receptor-PET provides additional information that can help guide management of NETs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|