Synthesis of oxo analogs of Lamotrigine and some related compounds

Autor: Iveta Wiedermannová, Pavel Hradil, Jan Slouka, Roman Buchtík, Jan Hlaváč
Rok vydání: 2003
Předmět:
Zdroj: ARKIVOC, Vol 2003, Iss 1, Pp 22-28 (2003)
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0004.103
Popis: Lamotrigine oxoanalog 8 was prepared using 5-(2-amino-5,6-dichlorophenyl)-6-azauracil 3 as starting compound. A series of 5-(2,3-dichlorophenyl)-6-azauracil derivatives 9–12 with additional substituents in the benzene ring were synthesized as well. The conversion of hydrazone 13 to derivative 14 containing two 6-azauracil rings is also described.
Databáze: OpenAIRE