A two-backbone polymer model for interphase chromosome geometry
| Autor: | B, Liu, R K, Sachs |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
Models Genetic Polymers General Mathematics General Neuroscience Immunology General Biochemistry Genetics and Molecular Biology Computational Theory and Mathematics Chromosomes Human Humans General Agricultural and Biological Sciences Interphase In Situ Hybridization Fluorescence Mathematics General Environmental Science |
| Zdroj: | Bulletin of Mathematical Biology. 59:325-337 |
| ISSN: | 1522-9602 0092-8240 |
| DOI: | 10.1007/bf02462006 |
| Popis: | A polymer model for the overall geometric structure of a human chromosome during the G0/G1 portion of cell-cycle interphase is constructed, based on fluorescence in situ hybridization data on distances between defined genomic sequences. The model consists of flexible giant loops, averaging about 6 million base pairs, with two random-walk backbones; it involves essentially three parameters. Numerical results based on properly selected values of parameters fit the data well. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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