Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure
| Autor: | Juan Alvarez, Christina Sobin, Mayra Gisel Flores-Montoya |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Lead Poisoning
Nervous System Childhood Male Litter (animal) Hippocampus Physiology Toxicology Article Mice Lactation Organometallic Compounds Animals Humans Medicine Recognition memory Memory Disorders Sex Characteristics Behavior Animal Dose-Response Relationship Drug business.industry Dentate gyrus Infant Newborn General Medicine Olfactory Perception Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Animals Newborn Lead Odor Maternal Exposure Lead acetate Exploratory Behavior Female business Sex characteristics |
| Zdroj: | Toxicology Letters. 236:69-74 |
| ISSN: | 0378-4274 |
| Popis: | Chronic developmental lead exposure yielding very low blood lead burden is an unresolved child public health problem. Few studies have attempted to model neurobehavioral changes in young animals following very low level exposure, and studies are needed to identify tests that are sensitive to the neurobehavioral changes that may occur. Mechanisms of action are not yet known however results have suggested that hippocampus/dentate gyrus may be uniquely vulnerable to early chronic low-level lead exposure. This study examined the sensitivity of a novel odor recognition task to differences in pre-adolescent C57BL/6J mice chronically exposed from birth to PND 28, to 0 ppm (control), 30 ppm (low-dose), or 330 ppm (higher-dose) lead acetate (N = 33). Blood lead levels (BLLs) determined by ICP-MS ranged from 0.02 to 20.31 µg/dL. Generalized linear mixed model analyses with litter as a random effect showed a significant interaction of BLL × sex. As BLLs increased olfactory recognition memory decreased in males. Among females, non-linear effects were observed at lower but not higher levels of lead exposure. The novel odor detection task is sensitive to effects associated with early chronic low-level lead exposure in young C57BL/6J mice. |
| Databáze: | OpenAIRE |
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