Genome-Wide Association Analysis of Ischemic Stroke in Young Adults
| Autor: | Christopher D. Anderson, Lynelle Cortellini, Braxton D. Mitchell, Nicole Dueker, Jeffrey R. O'Connell, Teri A. Manolio, O. Colin Stine, Mike A. Nalls, Sarah C. Nelson, Robert D. Brown, Karen L. Furie, Bradford B. Worrall, Hua Ling, Elizabeth W. Pugh, John W. Cole, Thomas G. Brott, Alessandro Biffi, Steven J. Kittner, Kimberly F. Doheny, Mary J. Sparks, Cathy C. Laurie, Stephen S. Rich, Yu-Ching Cheng, James F. Meschia, Patrick F. McArdle, Jess Shen, Jonathan Rosand, Natalia S. Rost |
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| Rok vydání: | 2011 |
| Předmět: |
Investigation
Genetics 0303 health sciences education.field_of_study Population FMNL2 Locus (genetics) Single-nucleotide polymorphism Biology Logistic regression 3. Good health 03 medical and health sciences 0302 clinical medicine Genotype SNP epidemiology brain infarction Young adult education Molecular Biology Genotyping 030217 neurology & neurosurgery Genetics (clinical) 030304 developmental biology |
| Zdroj: | G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| DOI: | 10.1534/g3.111.001164 |
| Popis: | Ischemic stroke (IS) is among the leading causes of death in Western countries. There is a significant genetic component to IS susceptibility, especially among young adults. To date, research to identify genetic loci predisposing to stroke has met only with limited success. We performed a genome-wide association (GWA) analysis of early-onset IS to identify potential stroke susceptibility loci. The GWA analysis was conducted by genotyping 1 million SNPs in a biracial population of 889 IS cases and 927 controls, ages 15–49 years. Genotypes were imputed using the HapMap3 reference panel to provide 1.4 million SNPs for analysis. Logistic regression models adjusting for age, recruitment stages, and population structure were used to determine the association of IS with individual SNPs. Although no single SNP reached genome-wide significance (P < 5 × 10−8), we identified two SNPs in chromosome 2q23.3, rs2304556 (in FMNL2; P = 1.2 × 10−7) and rs1986743 (in ARL6IP6; P = 2.7 × 10−7), strongly associated with early-onset stroke. These data suggest that a novel locus on human chromosome 2q23.3 may be associated with IS susceptibility among young adults. |
| Databáze: | OpenAIRE |
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