Scintimammography with 99mTc-MIBI versus dynamic MRI for non-invasive characterization of breast masses

Autor: Marco Salvatore, Silvana Del Vecchio, Francesca Di Gennaro, Albina Riccardi, A. Sodano, Massimo Imbriaco, Francesco Di Salle, Leonardo Pace
Přispěvatelé: Imbriaco, Massimo, Del Vecchio, S, Riccardi, A, Pace, L, Di Salle, F, Di Gennaro, F, Salvatore, Marco, Sodano, A., DEL VECCHIO, S, Pace, Leonardo, DI SALLE, F, DI GENNARO, F, Salvatore, M
Rok vydání: 2000
Předmět:
Technetium Tc 99m Sestamibi
medicine.medical_specialty
Biopsy
Breast Neoplasms
Scintigraphy
methods
Diagnosis
Differential
Computer-Assisted
Breast cancer
pathology/radionuclide imaging
Models
Diagnosis
Image Interpretation
Computer-Assisted
Humans
Medicine
Mammography
Radiology
Nuclear Medicine and imaging
Radionuclide Imaging
Image Interpretation
Models
Statistical
Scintimammography
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Magnetic resonance imaging
General Medicine
Statistical
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Differential
Dynamic contrast-enhanced MRI
Female
Radiology
Biopsy
Breast Neoplasms
pathology/radionuclide imaging
Diagnosis
Differential
Female
Humans
Image Interpretation
Computer-Assisted
Magnetic Resonance Imaging
Mammography
methods
Middle Aged
Models
Statistical
Radiopharmaceuticals
diagnostic use
Technetium Tc 99m Sestamibi
diagnostic use
Radiopharmaceuticals
business
Nuclear medicine
Breast carcinoma
Zdroj: European Journal of Nuclear Medicine. 28:56-63
ISSN: 1619-7089
0340-6997
DOI: 10.1007/s002590000411
Popis: Although mammography remains the technique of choice for the early detection of breast cancer, several imaging techniques, including scintimammography and magnetic resonance imaging (MRI), have recently been proposed as adjuncts for this purpose and included in many diagnostic protocols. This study was undertaken to assess the clinical accuracy of scintimammography with technetium-99m methoxyisobutylisonitrile (MIBI) and contrast-enhanced MRI in the detection of primary breast carcinoma in patients with equivocal mammographic findings. Forty-nine patients with a suspicious breast mass detected either by physical examination or by mammography and ultrasound (US) were studied. All patients underwent scintimammography and dynamic contrast-enhanced MRI 1 week apart. The results of the two techniques were compared and correlated to the final diagnoses. Two independent readers reported the scans using a four-point confidence scale. The areas under the receiver operator characteristic (ROC) curves were obtained. Scintimammography showed an accuracy for tumour detection of 84%, with a sensitivity of 80% and a specificity of 88%. MRI showed an accuracy of 86%, with a sensitivity and specificity of 96% and 75%, respectively. Comparison of the two areas under the ROC curves showed no significant differences between MRI, 0.91+/-0.05 (mean+/-SD), and scintimammography, 0.88+/-0.05 (P=0.9). It is concluded that dynamic MRI and scintimammography possess comparable accuracy in the diagnosis of primary breast carcinoma in patients with equivocal mammographic or US findings.
Databáze: OpenAIRE
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