Long-term doxorubicin release from multiple stimuli-responsive hydrogels based on α-amino-acid residues
| Autor: | I. Casolaro, Konstantinos D. Demadis, Barbara Del Bello, Emilia Maellaro, Mario Casolaro, Severino Bottari |
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| Rok vydání: | 2014 |
| Předmět: |
Stereochemistry
Stimuli-responsive hydrogels Pharmaceutical Science Phenylalanine In Vitro Techniques Basicity constants HeLa Magnetics Valine Spectroscopy Fourier Transform Infrared medicine Humans Doxorubicin Amino Acids Alternating magnetic field Doxorubicin release HeLa cells Magnetic nanoparticles Antibiotics Antineoplastic biology Chemistry Hydrogels General Medicine biology.organism_classification Controlled release In vitro Self-healing hydrogels Biophysics HeLa Cells Biotechnology medicine.drug |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 88:424-433 |
| ISSN: | 0939-6411 |
| Popis: | We have developed a series of pH- and temperature-stimuli-sensitive vinyl hydrogels, bearing α-amino acid residues ( l -phenylalanine, l -valine) and incorporating magnetic nanoparticles of different chemical compositions (CoFe2O4 and Fe3O4). The goal was to study the potential applications of these nanocomposites in the controlled release of doxorubicin (DOXO), a potent anticancer drug. The strength of the electrostatic interaction between the protonated nitrogen of the DOXO molecule and the ionized carboxylic groups of the hydrogel allowed effective control of the drug release rate in saline solutions. The embedded magnetic nanoparticles were an additional remote control of the drug release under the stimulus of an appropriate external alternating magnetic field (AMF). Data showed that the controlled release of DOXO proceeded for months and followed a diffusion-controlled release mechanism, while maintaining the amount of released drug within acceptable therapeutic windows. The amount of the released DOXO was found in all cases substantially higher than the “control” because the application of the AMF augments in stimulating the nanoparticles within the DOXO-loaded hydrogel. In vitro experiments have shown that the released DOXO is able to induce cell death to cervix adenocarcinoma cells (HeLa cells). |
| Databáze: | OpenAIRE |
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