Iodine status of UK schoolgirls: a cross-sectional survey
| Autor: | Mark P J, Vanderpump, John H, Lazarus, Peter P, Smyth, Peter, Laurberg, Roger L, Holder, Kristien, Boelaert, Jayne A, Franklyn, G R, Williams |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Adolescent Cross-sectional study Population Nutritional Status Physiology chemistry.chemical_element Ethnic origin Urine Iodine Excretion medicine Humans Sodium Chloride Dietary education Gynecology education.field_of_study business.industry Data Collection General Medicine medicine.disease Iodine deficiency United Kingdom Diet chemistry Female Thyroid function business |
| Zdroj: | Vanderpump, M P, Lazarus, J H, Smyth, P P, Laurberg, P, Holder, R L, Boelaert, K, Franklyn, J A & on behalf of the British Thyroid Association UK Iodine Survey Group 2011, ' Iodine status of UK schoolgirls: a cross-sectional survey ', Lancet, vol. 377, no. 9782, pp. 2007-12 . https://doi.org/10.1016/S0140-6736(11)60693-4 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(11)60693-4 |
| Popis: | Background: Iodine deficiency is the most common cause of preventable mental impairment worldwide. It is defined by WHO as mild if the population median urinary iodine excretion is 50–99 μg/L, moderate if 20–49 μg/L, and severe if less than 20 μg/L. No contemporary data are available for the UK, which has no programme of food or salt iodination. We aimed to assess the current iodine status of the UK population. Methods: In this cross-sectional survey, we systematically assessed iodine status in schoolgirls aged 14–15 years attending secondary school in nine UK centres. Urinary iodine concentrations and tap water iodine concentrations were measured in June–July, 2009, and November–December, 2009. Ethnic origin, postcode, and a validated diet questionnaire assessing sources of iodine were recorded. Findings: 810 participants provided 737 urine samples. Data for dietary habits and iodine status were available for 664 participants. Median urinary iodine excretion was 80·1 μg/L (IQR 56·9–109·0). Urinary iodine measurements indicative of mild iodine deficiency were present in 51% (n=379) of participants, moderate deficiency in 16% (n=120), and severe deficiency in 1% (n=8). Prevalence of iodine deficiency was highest in Belfast (85%, n=135). Tap water iodine concentrations were low or undetectable and were not positively associated with urinary iodine concentrations. Multivariable general linear model analysis confirmed independent associations between low urinary iodine excretion and sampling in summer (p |
| Databáze: | OpenAIRE |
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