Efficacy and safety of simvastatin for the treatment of hypercholesterolemia in patients with and without type II diabetes
| Autor: | G. Briani, A. Falluca, G.F. Pagano, Carlo Gabelli, E. Saibene, Gaetano Crepaldi, P. G. Da Col, Scipione Martini, Sandro Muntoni, Luigi Cattin |
|---|---|
| Přispěvatelé: | Martini, S, Gabelli, C, Pagano, Gf, Falluca, A, Muntoni, S, Saibene, E, Briani, G, Cattin, Luigi, DA COL, Pg, Crepaldi, G. |
| Rok vydání: | 1992 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Gastroenterology chemistry.chemical_compound Diabetes mellitus Internal medicine Medicine Pharmacology (medical) Adverse effect media_common Pharmacology Chemotherapy business.industry Cholesterol nutritional and metabolic diseases medicine.disease Endocrinology chemistry Simvastatin Metabolic control analysis lipids (amino acids peptides and proteins) business medicine.drug Lipoprotein |
| Zdroj: | Current Therapeutic Research. 52:281-290 |
| ISSN: | 0011-393X |
| DOI: | 10.1016/s0011-393x(05)80479-5 |
| Popis: | This multicenter study evaluated the efficacy and safety of simvastatin in patients with primary hypercholesterolemia and in patients with hypercholesterolemia associated with type II diabetes who were being treated with diet or oral antidiabetic agents. The metabolic control of diabetes during drug treatment was also evaluated. Of 90 patients from seven centers, 88 (48 nondiabetic and 40 diabetic) patients completed the study; 2 patients dropped out for reasons other than drug-related adverse events. Patients were admitted to the study if their total cholesterol was ⩾250 mg/dl, low-density lipoprotein (LDL) cholesterol was between 160 to 350 mg/dl, and total triglycerides were 200 mg/dl and again from 20 to 40 mg after 12 or 18 weeks if the goal cholesterol value ( 1c , did not change during the trial. Simvastatin is an effective and safe drug not only for the treatment of primary hypercholesterolemia but also for the treatment of hypercholesterolemia associated with type II diabetes. |
| Databáze: | OpenAIRE |
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