Surgery for Graves' disease: a 25-year perspective
| Autor: | Jesse M. Ehrenfeld, Antonia E. Stephen, Roy Phitayakorn, Dieter Morales-Garcia, Sareh Parangi, Gilbert H. Daniels, Randall D. Gaz, Carrie C. Lubitz, Jonathan P. Wanderer, Richard A. Hodin |
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| Rok vydání: | 2013 |
| Předmět: |
Ablation Techniques
Adult Male medicine.medical_specialty medicine.medical_treatment Graves' disease Operative Time Disease Malignancy Iodine Radioisotopes Postoperative Complications Antithyroid Agents Preoperative Care medicine Humans In patient Thyroid Neoplasms Retrospective Studies Incidental Findings Methimazole business.industry Optimal treatment Thyroidectomy Mean age General Medicine Perioperative Length of Stay medicine.disease Graves Disease Surgery Massachusetts Propylthiouracil Drainage Female business |
| Zdroj: | American journal of surgery. 206(5) |
| ISSN: | 1879-1883 |
| Popis: | BACKGROUND: Optimal treatment of Graves’ disease (GD) remains controversial. The authors retrospectively reviewed the surgical cases of GD at a single academic tertiary center. METHODS: Demographic, clinical, and surgical data were analyzed for all patients with GD undergoing thyroidectomy over 25 years, in 3 periods: 1985 to 1993 (n 5 32), 1994 to 2002 (n 5 91), and 2003 to 2010 (n 5 177). RESULTS: There were 300 patients with GD (85.7% women; mean age, 39.3 years; median length of follow-up, 24.6 months). Overall, perioperative morbidity occurred in 36 patients (12.0%), and there was no mortality. Thyroidectomy-specific morbidity was very low, and the incidental malignancy rate was 10.3%. CONCLUSIONS: Surgical treatment of GD has a very high safety profile, with low perioperative and thyroidectomy-specific morbidity, even in patients with overt hyperthyroidism. Incidental malignancy in patients with GD is not uncommon. 2013 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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