Pharmacokinetic aspects of the sublingual administration of vincamine
| Autor: | P P Leblanc, R Gomeni, J L Steimer, J M Aiache, J P Kantelip, M C Delatte |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Administration Sublingual Vincamine Administration Oral Pharmaceutical Science Absorption (skin) Pharmacology Models Biological Dosage form Intestinal absorption Sublingual administration Sublingual Absorption Random Allocation Pharmacokinetics Oral administration medicine Humans Pharmacology (medical) Vinca Alkaloids Chemistry General Medicine Intestinal Absorption medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 11:279-309 |
| ISSN: | 1099-081X 0142-2782 |
| Popis: | The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed. |
| Databáze: | OpenAIRE |
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