The central nervous norepinephrine network links a diminished sense of emotional well-being to an increased body weight

Autor: Donald Lobsien, Katrin Arélin, Karsten Müller, J. Melasch, Georg-Alexander Becker, Julia Luthardt, Michael Rullmann, Burkhard Pleger, Anja Hilbert, PM Meyer, M Patt, Osama Sabri, Arno Villringer, Swen Hesse, Yu-Shin Ding
Rok vydání: 2015
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Psychometrics
Endocrinology
Diabetes and Metabolism
Emotions
Hypothalamus
Medicine (miscellaneous)
Pilot Projects
Weight Gain
Body weight
Article
Body Mass Index
Norepinephrine
Young Adult
03 medical and health sciences
0302 clinical medicine
Germany
Internal medicine
Humans
Medicine
Norepinephrine metabolism
Norepinephrine Plasma Membrane Transport Proteins
Nutrition and Dietetics
Depression
business.industry
Reproducibility of Results
Middle Aged
Magnetic Resonance Imaging
Obesity
Morbid
Emotional well-being
stomatognathic diseases
030104 developmental biology
Endocrinology
Positron-Emission Tomography
Quality of Life
Female
Radiopharmaceuticals
medicine.symptom
business
Weight gain
Body mass index
030217 neurology & neurosurgery
medicine.drug
Zdroj: International Journal of Obesity
ISSN: 1476-5497
0307-0565
DOI: 10.1038/ijo.2015.216
Popis: Objectives: The neurobiological mechanisms linking obesity to emotional distress remain largely undiscovered.Methods: In this pilot study, we combined positron emission tomography, using the norepinephrine transporter (NET) tracer [11C]-O-methylreboxetine, with functional connectivity magnetic resonance imaging, the Beck depression inventory (BDI), and the impact of weight on quality of life–Lite questionnaire (IWQOL–Lite), to investigate the role of norepinephrine in the severity of depression (BDI), as well as in the loss of emotional well-being with body weight (IWQOL–Lite).Results: In a small group of lean-to-morbidly obese individuals (n=20), we show that an increased body mass index (BMI) is related to a lowered NET availability within the hypothalamus, known as the brain’s homeostatic control site. The hypothalamus displayed a strengthened connectivity in relation to the individual hypothalamic NET availability to the anterior insula/frontal operculum, as well as the medial orbitofrontal cortex, assumed to host the primary and secondary gustatory cortex, respectively (n=19). The resting-state activity in these two regions was correlated positively to the BMI and IWQOL–Lite scores, but not to the BDI, suggesting that the higher the resting-state activity in these regions, and hence the higher the BMI, the stronger the negative impact of the body weight on the individual’s emotional well-being was.Conclusions: This pilot study suggests that the loss in emotional well-being with weight is embedded within the central norepinephrine network.
Databáze: OpenAIRE
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